![]() As with other salad greens, there aren’t many carbs in iceberg lettuce (just two grams per shredded cup), as well as a negligible amount of protein (less than one gram) and virtually no fat, according to the USDA. Nutritionally speaking, all of these offerings are pretty similar in terms of not being a major source of macronutrients. By “regular” lettuce, let’s say we’re talking about things like romaine, red or green leaf lettuce, spinach, kale, or arugula, etc. What’s the difference between iceberg lettuce and regular lettuce? (The way we define “healthy eating” is pretty fraught anyway, given the influence of diet culture and discounting of important factors like joy and connection, food access, and culture.) Change the lettuce’s context by, say, sticking it in chicken and pepper fajitas or tucking it into a hummus and veggie wrap-foods that more people see as being healthier-and it starts to look a whole lot different. But because they usually don’t have the nutrition profile and glowing health halo of, say, a fiber-rich quinoa bowl, those foods tend to be looked down upon in the nutrition world-and by extension, iceberg lettuce does too. Of course, there’s nothing actually wrong with eating nachos or burgers, and all foods have their place in a varied, balanced diet. It’s typically thrown on top of things like nachos and burgers, or tossed with rich, creamy salad dressings, for instance. ![]() But first, another big reason for iceberg’s bad rap: the fact that it tends to get involved with foods and dishes that aren’t always seen as meeting our collective standard of good for you, notes Largeman-Roth. Enjoy within a few days, as the leaves are likely to wilt or spoil if stored beyond that time frame.We’ll talk more about comparing iceberg lettuce nutrition to its rival greens in a minute. Keep them refrigerated and be sure to wash and dry the leaves thoroughly before using. Look for different types of leafy greens at your local grocery store or farmers market. Kale can be baked into chips, which makes for a great tasting, healthy snack. They also can be added toward the end when making a homemade soup. For example, baby spinach leaves add a nice flavor and color when folded into an omelet. ![]() Greens also can be added to soups, stews, casseroles and other dishes. When cooked, greens can shrink down by half, so this is important to consider when planning meals. Try sautéing them in a little oil, then season with spices, such as garlic and just a little salt and pepper. Many leafy greens, such as spinach, kale and collard greens, also are well suited for cooking. For a mild flavor and delicate green color try mâche, Boston or Bibb lettuce.For flavor with a "bite" try chicory or escarole.For leaves that aren't green try red-and-white radicchio.For a peppery flavor try arugula or watercress.Perk up your salad-making with more flavor, color and texture by mixing in different greens. Check the Nutrition Fact Label or choose dressings made with oils more often, because they provide unsaturated fat, which is considered to be healthier than cream-based dressings. Greens supply lutein, which contributes to good vision and may help protect your eyes from macular degeneration, and they provide vitamin K, which plays a role in blood clotting and bone health.Ī small addition of fat can help with the absorption of certain nutrients. Some greens deliver folate, potassium and dietary fiber, too. For example, romaine has nine times more vitamin A than iceberg lettuce. The darker the leaves, the more nutrient-rich the lettuce. Mesclun, a mix of young salad greens, offers a variety of different types, such as arugula, frisée and radicchio, but the exact mix might vary.ĭark-green leafy greens offer plenty of the antioxidant beta carotene, which helps to form vitamin A in the body and may help lower the risk for certain diseases. Leafy greens can be either dark or light in color and include types such as spinach, romaine, kale, escarole, and endive. Lettuce, a type of leafy green, is one of the most commonly eaten veggies in the United States. Monkey Business Images/Monkey Business/Thinkstock
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![]() He was a child prodigy and a virtuoso pianist. Liszt was born sixteen years before Beethoven’s death. This brings us to Franz Liszt (1811-1886). These changes transformed a delicate instrument into an incredibly powerful beast that can replace an orchestra but that at the same time retains the gentleness of its ancestors. The biggest differences between the pianoforte and fortepiano (the modern piano) are, first, that the frame the harp strings are tied to is not wooden but metal the low-tension strings have been replaced with high-tension ones the instrument has a range of two additional octaves (14 extra white keys) and the hammers are covered with tightly compacted felt instead of leather. He complained to the piano manufacturer that pianos wore out very fast. At one point he had broken 78% of the strings in his piano. Beethoven was one of the early adopters and beneficiaries of the piano’s evolution and played an important role in the evolution of the instrument. This transformation had a major impact on the music that was composed and, in a musical feedback loop, composers impacted the instrument. But from the late 1700s to the early 1800s the piano underwent a significant transformation. Mozart died in 1791, just as the fortepiano (or simply, piano), the instrument we are all familiar with, was starting to emerge. Think of Mozart’s piano concertos or sonatas, which were written for pianoforte. Each note is very clear and distinct, and the pianoforte has still not completely lost the sound of the harpsichord. The sound of the pianoforte is different from the sound we accustomed to hearing today: it is lighter, and the instrument did not have a double escape mechanism and thus could not repeat sounds rapidly – it speaks instead of signing. This is the instrument used by Mozart and the young Beethoven. The frame that held the strings was still wooden, and the strings were held at low tension. In fact it was called a harpsichord – think of it as a harp (wooden frame with stretched strings) with a keyboard.Īround 1700 the harpsichord gradually transformed into a pianoforte, which had the same look as the harpsichord, but instead of the strings being plucked they were hit by little leather-wrapped hammers. Though the earlier instrument had a similar shape and had a keyboard, its interior plumbing was completely different. The piano you see today in concerts hall or in private homes was not always like that. I don’t think you can talk about Liszt without talking first about the evolution of the piano. Legend has it that Beethoven kissed Liszt on the brow after the young boy played him his Archduke Piano Trio from memory with the missing violin and cello parts incorporated as he went along.Listen on: iTunes | Google Podcasts | Onlineįranz Liszt was a Hungarian composer and pianist. July 1886 he died from dropsy complicated by pneumonia. The rest of his life was dominated by a series of inspired sacred compositions, while his piano music became more calmly reflective and meditative in tone.Īctive to the end, even in 1886 (the year of his death) Liszt was on a tour which embraced his first visit to London in more than 40 years. Such was his devotion to the church that Pope Pius IX conferred on him the title of ‘Abbé’ four years later. In 1848, Liszt accepted a full-time professional post in Weimar where he increasingly turned his attention towards composing. He started every performance by ceremoniously removing a pair of white gloves and he invariably employed a second piano on stage so that onlookers could admire his prowess from every conceivable angle. Some particularly horrific scenes during the Paris cholera epidemic of 1832 so moved him that he once spent all night thrashing out the Dies Irae (Day of Wrath) chant on the piano.īetween 18 Liszt gave well over a thousand concerts throughout most of western Europe, Turkey, Poland and Russia, stunning audiences wherever he went with his blend of pianistic devilry and showbiz razzmatazz. Liszt developed a morbid obsession with death in the 1830s. Liszt’s early progress was so astounding that by the age of nine he had already mastered Ferdinand Ries’s excruciatingly difficult E flat major Piano Concerto. Liszt’s output for solo piano was prodigious, centered on a core of more than 100 original titles, many of which subdivide into sets of half-a-dozen pieces or more. His compositions inspired a whole generation of keyboard virtuosi. Franz Liszt (1811–1886) was one of the most important composers of the Romantic period. Suburbianity is an expose of modern American Christianity and the myths it is built around. It crossed the Atlantic to America and became a big business.” It traveled to Europe and became a culture. It moved to Rome and became an institution. As Robert Webber said, “The church started as a missionary movement in Jerusalem. If you can picture starving to death while stuffing yourself at an all you can eat buffet, you have an excellent image of the modern American church in your mind. You should buy this book, you should quit reading whatever you’re currently reading and read this book, and then you should buy a case of these books and give them to any Christian who will take one. You might even end up excited about the potential for the church in suburban America as you let the power of the Gospel fill you with hope. Thankfully, this book also left me encouraged because the solution to the problem is a simple one – let the gospel smash our “suburbianity” to bits and let gospel resonate in every area of our lives. This book quite often made me feel awkward and embarrassed as my own “suburbianity” was exposed. I can think of few books which have so effectively used Scripture to highlight both the problem being address as well as the solution. The contrast between the religion of the American suburbs and the message of the Bible described in this book is jarring, but I think few suburban Christians would be able to find grounds to disagree with Mr. In truth, this book will probably make you feel like a kid who got pushed out of the locker room in his underwear. ![]() This book won’t make you feel warm and fuzzy. In the last area the challenge is for the roots of the gospel to grow deep in the soil of our hearts, and to let gospel be the incessant proclamation of our words and deeds. Yawn works to press the importance of understanding that the Bible is all about Jesus, rather than all about me and my life. In the second area we are shown how the church fails miserably by assuming that people in the third world, those in urban centers, and those trapped in poverty need to hear the gospel, but not my neighbor with the three car garage and certainly not the people sitting in the pews. It is a complete misunderstanding of what we’ve been saved from and for what purpose we have been saved. In the first area the reader is made to realize that the problem griping the suburban church is so much more than mere consumerism. In the main body of the book Yawn addresses four specific areas: the effects of the suburbs on Christianity, the way we assume people know and embrace the gospel, the mess we’ve made of the Bible and its core message, and decluttering our concept of the church. Yawn writes, “…my target audience is the Christians wandering aimlessly out in the American suburbs, unaware that they are currently imbibing a designer religion that has no essential relationship to Christianity.” ![]() ![]() Yawn use the introduction to paint a picture of the church in suburban American, and to address the great need of a people who are buried in a kind of church culture, but who fail to realize that their religion bears little resemblance to biblical Christianity. Suburbianity begins with a rather lengthy introduction, but it serves the book well and should be regarded as the book’s first chapter. We have made ourselves and our American dreams the main thing and pushed the main thing – Jesus Christ, and His rescue of sinful humanity through His life, death, burial, and resurrection – to the bottom of the list. The problem according to Byron Yawn is that the church, the American church, the suburban, American church, has failed miserably in keeping the main thing the main thing. “The main thing is to keep the main thing the main thing,” is perhaps Stephen Covey’s most well known quote, and it is one which translates well into the life of the church. ![]() However, if you do want to cater to your whole family with cakes, then you might need that 5 quart capacity, or potentially even more, such as the KitchenAid Pro Line Stand Mixer. If I was to invest in a stand mixer, I would opt for the KitchenAid Artisan Mini Stand Mixer due to the fact it is endearingly small, and because I don't need a large capacity for my bakes. (Image credit: Future/Molly Cleary) Should you buy the KitchenAid Artisan Mini Stand Mixer? The KitchenAid Artisan Stand Mixer is everyone's favorite mixer for a reason, and won't let you down when it comes to capacity, performance, and aesthetics. However, if you're looking to get the most from your investment, then the Mini won't tick all of your boxes, as the capacity is reduced, and the power is much less in terms of watts. This mixer is bound to impress, and you'll be enamored by it the minute you see it. That means that if you're considering investing, you should take the plunge if you really need a smaller model or if you like the sound of a miniature version. ![]() When it comes to comparing the KitchenAid Artisan Mini Stand Mixer to the full-sized alternative, the essential information you need is that it's 25% smaller, $20.00 cheaper and that it performed just as well as the bigger model in our tests. As far as the exterior is concerned, the stainless steel can be wiped down to ensure your new investment remains sparkling clean. In terms of the attachments, the dough hook and beater head can be put in the dishwasher too, but the wire whip should be hand washed, so that the intricate shape remains the same. ![]() The bowl can be put into the dishwasher as soon as you're finished with it, and the fact that it is considerably smaller means that even if you have a smaller capacity dishwasher, the bowl should fit in. You can see the dough turning and folding as the mixer works too, so if there is a particular dough consistency you need, you need keep an eye on the process.Īnother benefit of the mini size of this mixer is that clean-up is bound to be easier. The results were achieved in just a couple of minutes, saving your arms from strenuous work. Using the medium speed, the consistency of the dough came together well, yielding a smooth springy dough. We made a wholemeal loaf using this mixer, to get an idea of how valuable it is as an attachment. To attach it to your mixer, you simply need to lift the head using the dial and rotate it until it clicks into place. It has a C-shape claw that mimics the motion of hand kneading but requires absolutely none of the effort. The dough hook that is included with this mixer is perfect for breadmaking. Some mixers can shake and shudder when the power gets too high, but this mixer worked quietly and efficiently without being a nuisance. Despite the smaller size, the KitchenAid Artisan Mini Stand Mixer excelled at this test, and on a medium setting it felt powerful but not out of control. With that in mind, we set out to bake a Victoria sponge cake using the all-in-one method.Īs you can see from the images, the test of this mixer was conducted at the same time as various full-size mixers. Kitchenaid recommends using the flat edge beater for mixing ingredients, as the scraper is optimally designed to ensure that the sides and bottom of the mixing bowl are taken care of. In order for you to get an accurate picture of what this mixer is like to use, we used each of these attachments in different tests to gauge their abilities. In the box with this mixer, there are three attachments: a flat-head beater, a wire whisk, and a dough hook. You can simply use the speed dial to switch between the ten available settings. Once the head is secured down and your ingredients have been added, the speed control is ultra-convenient. That includes the tilt-head feature, which allows you to maneuver the mixer up and down as you add ingredients and take a break from mixing. This mixer has an identical design aside from the size of its bigger predecessor, which you can discover more about in our KitchenAid Artisan Stand Mixer review. More: Anycubic Photon M3 Premium Resin 3D Printer Review Best Medium Format Resin 3D Printerįour bolt build platform leveling can be difficult to clean The included Anycubic Photon Workshop software was slow and buggy during our testing, and is the primary weak point of this machine. With a special introductory retail price of $619 and a planned retail price of $639, the Photon M3 Premium strikes an excellent balance between high resolution and large build volume while remaining less expensive than the competition. Featuring integrated dual air filters, a laser-etched build platform, and a razor-thin NFEP vat film, the Photon M3 Premium is easily capable of handling anything you can throw at it. The 219mm x 123mm x 250mm build volume allows users to print large models with high resolution, or simply pack the oversized build platform with multiple small parts to produce many in parallel. ![]() We were particularly impressed when we printed a model that had a tiny, open book on a pedestal the words on the pages were sharp and legible (though one might need a magnifying glass to see them). The 10-inch 8K masking LCD provides an ultra-high 0.0285mm XY resolution which allows even the finest details to resolve on printed models. Offering both high resolution and large build volume in a single machine, it effectively does the work of two separate printers and still comes in cheaper than buying them individually. ![]() The Anycubic Photon M3 Premium set an impressive standard. Photon Workshop software feels clunky and slow More: Phrozen Sonic Mighty 8K Review Best Super-Large Format Resin 3D Printer That's nearly half the cost of the Mighty 8K. There’s no set date on when the camera firmware will be ready, but it promises the ability to monitor prints as well as create time lapses.įor a more affordable 8K resin option, consider the Phrozen Sonic Mini 8K S which still offers amazing print detail and now compatible with all the popular 3rd party slicers but is only $349.99. Our only issue with this machine was the camera, which was released for review before it was functional. We were able to print 12 very-detailed gaming figures at once and the process only took 4 hours and 2 minutes. The quality and extra wiggle room would be a worthwhile investment for someone running an Esty shop or an artist wanting to showcase their work. The Phrozen Sonic Mighty 8K size is closer to what we see in FDM printers, without being so large that it dominates your workshop. I found this extremely helpful while dialing in a new resin. Want to rerun a test file at a different exposure? No problem – the Sonic Mighty 8k will let you change exposure settings and more right inside the printer. There’s little need to consult the manual – the printer walks you through an onboard tutorial to handle leveling and your first test print. We enjoyed navigating through the Mighty 8K’s menus, thanks to its large and easy-to-use touch screen display. But in return for the premium, you get crispy details, prints that practically slide off the build plate, a built-in webcam and a machine that’s WiFi ready. Priced at around $600 at press time, this printer isn't cheap. ![]() Its roomy 218 x 123 mm build plate can accommodate an army of gaming miniatures or a gift-worthy superhero statue. If you’re ready to throw some serious cash down for a decent-sized resin 3D printer with quality that will knock your socks off, the Phrozen Sonic Mighty 8K is here for you. More: Anycubic Photon Mono M5s Review Best Resin 3D Printer for Beginners With all these and more "smart" features the Photon Mono M5s has to offer, it is a great option for makers looking for a mid-size high-resolution printer and also a smart buy as it is also $40 off its usual $539 MSRP. Just add resin and you are ready to go.Īnycubic has also come out with its own specialty high-speed resin (sold separately or included in bundle kits) which works with the M5s and is the secret sauce that helps to cut the time of your prints tremendously. This is the first resin printer we've tested that provides auto-leveling using mechanical sensors which not only saves time but also makes it super easy to set up. Anycubic claims this printer has the ability to reach an average print speed of 105mm/hour, so if you are looking for a high speed, high res printer, the M5s has you covered.Īmazingly, the Photon Mono M5s doesn't require any manual calibration. In our test, we're able to print a 3.5-inch model in less than an hour. When it comes to printing in detail, nothing comes close to the Anycubic Photon Mono M5s which features a whopping 12K resolution and achieves 19 micron X accuracy. There are hundreds of different items (weapons, materials, armor etc) in the game, to be found or crafted by the player. There are currently six fully developed biomes out of a planned total of eight (plus the Ocean). ![]() Single-player and multiplayer modes are fully functional and we have a separate dedicated server tool if you want a server running 24/7. “Most planned core features of the game have been implemented. What is the current state of the Early Access version? In addition, we also plan to add more unique locations and events for you to find in the world of Valheim.” We also want to add more types of weapons and build-pieces so you can further customize your viking stronghold, and make it withstand new threats. We want to expand the crafting system with new crafting stations, and more recipes. What we will add is a ton of more content in the form of new biomes, new enemies, new bosses, and new materials to find. “The basic functionality of the game will remain pretty much the same, except Biome-specific gameplay challenges. How is the full version planned to differ from the Early Access version? Aside from the large biome updates, we also want to add smaller updates to fill out the game.” It’s a pretty safe bet to say that Valheim will be in active development for at least another two years (counting from January 2023). ![]() We’re currently working on our seventh biome, the Ashlands, and after that we have one more to complete (the Deep North) before we’ll consider the game to be version 1.0. Early Access is a way for us to receive valuable feedback that ensures the quality of the game is up to par, as well as to collaborate with our players on what they want to see in the game.”Īpproximately how long will this game be in Early Access? Valheim is already a pretty big game but we still have a ton of things that we want to add. “We want to make a truly great game, and we believe working directly with our community is the best way to succeed with that. ![]() You may move or resize the spiral by clicking inside the spiral or on one of the handles. The new spiral becomes the only selected object after creation. The blue handle is used to squish or give a tilted look to the spiral. The two intermediate handles allow the radius to transition along the spiral, create a "conch" shell appearance. The spiral may be wound or unwound using the handles at the start (center) and end of the spiral. When selected 6 handles are available to adjust the number of turns, outside radius, starting and ending points, and a "tilt" for the spiral. The shape of the spiral may be edited after creation. The final spiral is positioned when the process is completed by releasing the mouse. The opposite corner of the virtual enclosing rectangle moves with the mouse drag action. The mouse down click places one corner of a virtual rectangle that encloses the rectangle. ![]() The new spiral is shown as you drag the mouse. The spiral is drawn with the mouse by a single click and drag sequence. ![]() The "Rectangular Creation Cursor" (shown above) will reflect the tool selection when the mouse is over the front (top) document window. Spirals are drawn by clicking the "Spiral Tool Button" on the "Tools Palette". The desired window must be brought to the front before clicking on the tool. The new spiral will be drawn on EazyDraw’s front window. If the palette is not visible open it by selecting "Tools" from the "View" item of the "Main Menu". You use the "Spiral Tool" (shown above) which is found on the Tools Palette to create spirals. ![]() Outside the window, a few ships are parked illegally – TARDIS (Doctor Who), Enterprise (Star Trek), Galactica (Battlestar Galactica) and Serenity (Firefly).įor those of you who need to recognize the animals – The cat is from Sabrina, next to Jack is Vincent and Eddie from Fraiser is also running about. ![]() On the left, between couches, is Buffy the Vampire Slayer trying to slay Bill Compton from True Blood. Chuck, from Chuck, is flirting with Purple Haired Sydney Bristow from Alias. No matter where you are in the world or what surfaces youre painting or coating, Sherwin-Williams provides innovative paint solutions that ensure your. i am literally in love with that cute little nerd and dont know why theres not many Dipper X reader and for lemons there is not much of just normal sweet dipper x reader lemonadess >< Ill still do Bipper, Revers. Next to them are Claire from Heroes and Jeff from Community.īehind the Couch – Sheldon Cooper from The Big Bang Theory is talking to one of his heroes, Spock from Star Trek. wattpad fanfiction So basically this is a book with lemons (Literally my specialty ) and fluff etc. Sherlock Holmes from, well, Sherlock, is having fun with Dexter Morgan, from, well, Dexter.īottom Couch – Don Draper looks cooler than anyone should be (Mad Men), sitting next to Barney from How I Met Your Mother. The goal of this web optimized port is to. Web minecraft herobrine reader fanfiction fantasy nether x reader. Yandere father x male child reader lemon while kyle x cartman, kyle x stan, kenny x kyle. (Lemon) Levi x Reader - Rougher is better, an attack on titan/ fanfic FanFiction (Lemon) Levi x Reader - Rougher is better By: KurooUsagii-chan Levi is not the kind of guy who would kiss your tears away as he rams himself inside of you, neither is he the kind of guy to restrain himself to help you out. Right Side, going down – The Doctor, from Doctor Who, is annoying Walter from Breaking Bad. completed book 1 a minecraft mob talker girls x reader story. Rick Grimes from the Walking Dead is crouching in the corner. Back Wall – Tobias from Arrested Development not really understanding why River from Firefly is hiding behind the TV. ![]() My personal opinion on this is that it is horrible. T he new big feature this year is Madden backtrack. New Madden players may have a little trouble with the punt or field goal controlls but gets very easy around the 3rd try. There is help with all the controlls so you don't have to stop everything and refer to the manual while in the middle of a game. Even if you have just started to play Madden it is very easy to learn and is self explanatory. On fiels condition are very good in graphics and players look very good. There is not as much body warping as in earler Madens but the problem does still pop up every now and then. Graphics on the fans in the stands needs a little help, they look all messed up. They need to add more tackles beacause it just gets old after a while. Madden NFL 09 also provides fans of online play with their most robust set of options yet, featuring trades and statistical tracking for leagues of up to 32 teams, and a new flex-scheduling option that lets two people compete whenever they are both online. The graphics have been tweaked to improve player physiques and create more realistic weather and lighting effects, while new animations include fluid juke move deviations, missed field goal returns, bobbled catches, and user-controlled touchdown celebrations. The new Backtrack feature gives Collinsworth the chance to analyze the last play (complete with telestrator) and tell gamers where they may have gone wrong, and players can then use the Rewind feature to try the same play again. Games themselves have been given a new presentation style, featuring pre-game stadium shots that showcase the pomp of player introductions, lively sidelines full of camera crews, and broadcast-style commentary from NFL Network announcers Tom Hammond and Cris Collinsworth. The My Skill difficulty level adjusts after every game, and players can enter the Tron-esque Virtual Trainer to increase their proficiency in any particular area. The game then offers players the chance to compete in the four standard difficulty levels, or the new custom "My Skill" difficulty level specifically tailored to their play style. Chief among the new offline features is the Adaptive Difficulty Engine, which determines players' "Madden IQ" by judging their ability to run, pass, and defend. The constant tweaking of the series continues as well, with the "09" entry unveiling an assortment of new features and updated graphics and animation. The most recognizable franchise in video game sports returns for a 20th season of gridiron action in Madden NFL 09.Continued abuse of our services will cause your IP address to be blocked indefinitely. Please fill out the CAPTCHA below and then click the button to indicate that you agree to these terms. If you wish to be unblocked, you must agree that you will take immediate steps to rectify this issue. If you do not understand what is causing this behavior, please contact us here. If you promise to stop (by clicking the Agree button below), we'll unblock your connection for now, but we will immediately re-block it if we detect additional bad behavior. Overusing our search engine with a very large number of searches in a very short amount of time.Using a badly configured (or badly written) browser add-on for blocking content.Running a "scraper" or "downloader" program that either does not identify itself or uses fake headers to elude detection.Using a script or add-on that scans GameFAQs for box and screen images (such as an emulator front-end), while overloading our search engine.There is no official GameFAQs app, and we do not support nor have any contact with the makers of these unofficial apps. ![]() Continued use of these apps may cause your IP to be blocked indefinitely. This triggers our anti-spambot measures, which are designed to stop automated systems from flooding the site with traffic. 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The latest version of the Opera browser sends multiple invalid requests to our servers for every page you visit.The most common causes of this issue are: Your IP address has been temporarily blocked due to a large number of HTTP requests. ![]() MODULE 3: Diagnosis and Management of Adverse Events Associated with Immune Checkpoint Inhibitors Alone and in Combination for Endometrial Cancer - Dr Westin Potential ramifications of the emerging positive results from the RUBY and NRG-GY018 trials for the management of pMMR endometrial cancer.Response rates observed with single-agent dostarlimab among patients with recurrent and/or advanced pMMR disease in the GARNET trial.Design, eligibility criteria and key efficacy and safety endpoints for the Phase III LEAP-001 trial comparing pembrolizumab/lenvatinib to chemotherapy as first-line treatment for advanced or recurrent endometrial cancer estimated completion date.Antitumor efficacy observed with pembrolizumab/lenvatinib in patients with MSI-H/dMMR endometrial cancer in the KEYNOTE-775 trial current nonresearch role, if any.Key efficacy and safety data with pembrolizumab in combination with lenvatinib for patients with previously treated advanced pMMR tumors in the KEYNOTE-775 trial.Biologic rationale for combining immune checkpoint inhibitors with VEGF inhibitors for pMMR endometrial cancer. ![]() MODULE 2: Immunotherapy-Based Strategies for Patients with MMR-Proficient (pMMR) Endometrial Cancer - Dr Coleman Emerging positive results from the Phase III RUBY and NRG-GY018 studies evaluating dostarlimab and pembrolizumab, respectively, in combination with chemotherapy for advanced or recurrent endometrial cancer potential implications for the management of MSI-H/dMMR disease.Antitumor efficacy observed with pembrolizumab/lenvatinib among patients with MSI-H/dMMR endometrial cancer in the KEYNOTE-775 trial current nonresearch role, if any.Available clinical trial data with other anti-PD-1/PD-L1 antibodies (eg, durvalumab, atezolizumab) for patients with MSI-H/dMMR endometrial cancer.Current clinical roles for dostarlimab and pembrolizumab monotherapy in the treatment of MSI-H/dMMR advanced endometrial cancer optimal integration into practice.Efficacy and safety findings with pembrolizumab monotherapy for the cohort of patients with previously treated MSI-H/ dMMR advanced endometrial cancer in the KEYNOTE-158 study.Key efficacy and safety data with dostarlimab for patients with advanced or recurrent MSI-H/dMMR tumors in the.Current indications for MSI/MMR testing in patients with endometrial cancer available testing platforms.MODULE 1: Immune Checkpoint Inhibitors for Patients with Advanced Microsatellite Instability-High (MSI-H)/Mismatch Repair-Deficient (dMMR) Endometrial Cancer - Dr Powell 11:15 AM – 11:45 AM - Registration and Lunch Buffet |
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